google scholar profile (Prof. Tamar Juven-Gershon)


Functional Screening of Core Promoter Activity.

Even, D.Y., Kedmi, A., Ideses, D. and Juven-Gershon, T. (2017) Methods Mol Biol. 1651, 77-91   PubMed


Structural and dynamics characterization of the MerR family metalloregulator CueR in its repression and activation states

Sameach, H., Narunsky, A., Azoulay-Ginsburg, S., Gevorkyan-Aiapetov, L., Zehavi, Y., Moskovitz, Y., Juven-Gershon, T., Ben-Tal, N. and Ruthstein, S. (2017)  Structure25(7), 988-996.e3   PubMed


SELMAP - SELEX affinity landscape MAPping of transcription factor binding sites using integrated microfluidics

Chen, D., Orenstein Y., Golodnitsky R., Pellach M., Avrahami D., Wachtel C., Ovadia-Shochat A., Shir-Shapira H., Kedmi A., Juven-Gershon T., Shamir R., and Gerber D. (2016) Scientific Reports, 6, 33351  PubMed


Engineered Promoters for Potent Transient Overexpression

Even, D.Y.*, Kedmi A.*, Basch-Barzilay, S.*, Ideses, D., Tikotzki, R., Shir-Shapira, H., Shefi, O. and Juven-Gershon, T. (2016)  PLOS ONE, 11(2): e0148918  PubMed  PDF


ElemeNT: A Computational Tool for Detecting Core Promoter Elements

Sloutskin, A., Danino, YM., Orenstein, Y., Zehavi, Y., Doniger, T., Shamir, R. and Juven-Gershon, T. (2015)  Transcription, 6(3), 41-50  PubMed  PDF

Here you can find the described resources.


Structure-Function Analysis of the Drosophila melanogaster Caudal provides insights into core promoter-preferential activation

Shir-Shapira, H.*, Sharabany,J.*, Filderman, M., Ideses, D., Ovadia-Shochat, A., Mannervik, M. and Juven-Gershon, T. (2015)  Journal of Biological Chemistry, 290(28) 17293-305  PubMed  PDF


The core promoter: at the heart of gene expression

Danino,Y.M, Even, D., Ideses, D.,  and Juven-Gershon,T. (2015)  BBA Gene Regulatory Mechanisms, 1849(8), 1116-31  PubMed  PDF


TRF2: TRansForming the view of general transcription factors

Zehavi, Y.*, Kedmi, A.*, Ideses, D., and Juven-Gershon, T. (2015) Transcription, 6(1), 1-6  PubMed   PDF


The FOXO Transcription Factor DAF-16 Bypasses ire-1 Requirement to Promote Endoplasmic Reticulum Homeostasis

Safra M., Fickentscher R., Levi-Ferber M., Danino Y.M., Haviv-Chesner A., Hansen M., Juven-Gershon T., Weiss M., Henis-Korenblit S. (2014)  Cell Metabolism, 20, 870-881 PubMed 


TRF2 Is a Preferential Core Promoter Regulator

Kedmi, A.*,  Zehavi, Y*.,  Glick, Y., Orenstein, Y., Ideses, D., Wachtel, C.,  Doniger, T., Waldman Ben-Asher, H., Munster, N., Thompson, J., Anderson, S., Avrahami, D., Yates, JR 3rd, Shamir, R., Gerber, D., and Juven-Gershon, T. (2014) Genes & Development, 28, 2163-2174  PubMed  PDF


The core promoter composition establishes a new dimension in developmental gene networks
Zehavi, Y., Sloutskin, A., Kuznetsov, O., and Juven-Gershon, T. (2014)  Nucleus, 5:4, 298–303  PubMed  PDF


Core promoter functions in the regulation of gene expression of Drosophila Dorsal target genes

Zehavi, Y., Kuznetsov, O., Ovadia-Shochat, A. and Juven-Gershon, T. (2014)  Journal of Biological Chemistry, 289, 11993-12004  PubMed  PDF


Human TFIID binds to core promoter DNA in a reorganized structural state

Cianfrocco, M.A., Kassavetis, G.A., Grob, P., Fang, J., Juven-Gershon, T., Kadonaga, J.T. and Nogales, E. (2013)  Cell, 152, 120-131  PDF


Regulation of gene expression via the core promoter and the basal transcriptional machinery

Juven-Gershon, T. and Kadonaga, J.T. (2010)  Developmental Biology, 339, 225-229  PDF

- One of the top-five most cited articles published in the journal Developmental Biology during the period 1/1/2009-31/12/2011 


Caudal, a key developmental regulator, is a DPE-specific transcriptional factor

Juven-Gershon, T., Hsu, J.-Y. and Kadonaga, J.T. (2008) Genes & Development, 22, 2823-2830  PDF


TBP, Mot1, and NC2 establish a regulatory circuit that controls DPE-versus TATA-dependent transcription

Hsu, J.-Y, Juven-Gershon, T., Marr, M.T. 2nd, Wright, K.J., Tjian, R. and Kadonaga, J.T. (2008) Genes & Development, 22, 2353-2358  PDF


The RNA polymerase II core promoter – the gateway to transcription

Juven-Gershon, T., Hsu, J.-Y. Theisen J.W.M. and Kadonaga, J.T. (2008) Current Opinion in Cell Biology, 20, 253-259  PDF


Perspectives on the RNA polymerase II core promoter

Juven-Gershon, T., Hsu, J.-Y. and Kadonaga, J.T. (2006)  Biochemical Society Transactions 34, 1051-1054  PDF


Rational design of a super core promoter that enhances gene expression

Juven-Gershon, T., Cheng, S. and Kadonaga, J.T. (2006) Nature Methods, 3, 917 - 922  PubMed

- Potential applications of this study were discussed in: Perkel, J.M. (2007) Studies you can use. The Scientist, 21,63


Siah1 binds and regulates the function of Numb

Susini, L.*,Passer, B.J.*,Amzallag-Elbaz, N.*, Juven-Gershon, T.*, Prieur, S., Privat, N., Tuynder, M, Gendron M., Israel, A., Amson, R., Oren, M. and Telerman, A. (2001)  Proc. Natl. Acad. Sci. USA, 98, 15067-15072  PDF

*The first four authors contributed equally to this paper


Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

Unger, T.*, Juven-Gershon, T.*, Moallem, E.*, Berger, M., Vogt-Sionov, R., Lozano, G., Oren, M. and Haupt, Y. (1999)  EMBO J., 18, 1805-1814  PDF

*The first three authors contributed equally to this paper


The c-fos proto-oncogene is a target for transactivation by the p53 tumor suppressor

Elkeles, A., Juven-Gershon, T., Israeli, D., Wilder, S., Zalcenstein, A. and Oren, M. (1999)  Molecular & Cellular Biology, 19, 2594-2600  PDF


Mdm2: the ups and the downs

Juven-Gershon, T. and Oren, M. (1999)  Molecular Medicine, 5, 71-83 PDF  


The Mdm2 oncoprotein interacts with the cell fate regulator Numb

Juven-Gershon, T., Shifman, O., Unger, T., Elkeles, A., Haupt, Y. and Oren, M. (1998)  Molecular & Cellular Biology, 18, 3974-3982 PDF 


Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

Barak, Y., Gottlieb, E., Juven-Gershon, T. and Oren, M. (1994) Genes & Development, 8, 1739-1749 PDF


Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene

Barak, Y., Lupo, A., Zauberman, A., Juven, T., Aloni-Grinstein, R., Gottlieb, E., Rotter, V. and Oren, M. (1994)  Cold Spring Harb Symp. Quant. Biol., 59, 225-235  PubMed


Antibodies to different isoforms of the heavy neurofilament protein (NF- H) in normal aging and Alzheimer's disease

Soussan, L., Tchernakov, K., Bachar-Lavi, O., Juven, T., Wertman, E. and Michaelson, D.M. (1994) Molecular Neurobiology, 9, 83-91  PubMed


Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene

Juven, T., Barak, Y., Zauberman, A., George, D.L. and Oren, M. (1993) Oncogene, 8, 3411-3416 PubMed


mdm2 expression is induced by wild type p53 activity

Barak, Y., Juven, T., Haffner, R. and Oren, M. (1993) EMBO J., 12, 461-468  PDF




Optimized core promoters and uses thereof

Kadonaga and Gershon. Patent no. US 7,968,698 B2: 2006.

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